Form 13F security

IONS · IONIS PHARMACEUTICALS INC.

Class COM

As filed on Form 13F — long US-listed positions only. No shorts, cash, bonds, or non-13F assets appear here.

Filed up to 45 days after quarter end; holdings may have changed since.

Tracked managers holding it

Share and principal positions

ManagerQuarterValue% of portfolioSH/PRN qtyPut/call
Tweedy, Browne Co LLC2026-06-30$181M13.7%SH 2,280,311
Fisher Asset Management, LLC — Ken Fisher2026-06-30$11M<0.1%SH 137,184
HORIZON KINETICS ASSET MANAGEMENT LLC2026-06-30$0.9M<0.1%SH 10,904

Total $193M across 3 of 69 managers.

Put positions

ManagerQuarterValue% of portfolioSH/PRN qtyPut/call
Point72 Asset Management, L.P.2026-06-30$1.1M<0.1%SH 13,900[PUT]

Total $1.1M across 1 of 69 managers.

Call positions

ManagerQuarterValue% of portfolioSH/PRN qtyPut/call
Point72 Asset Management, L.P.2026-06-30$1.6M<0.1%SH 20,300[CALL]

Total $1.6M across 1 of 69 managers.

Sums are across tracked reports, not unique economic ownership.

Filed rows (5) — as filed
ManagerClassPut/callValue% of portfolioSH/PRN qtySource
Tweedy, Browne Co LLCCOM$181M13.7%SH 2,280,3110001193125-26-340443
Fisher Asset Management, LLCCOM$11M<0.1%SH 137,1840000850529-26-000006
Point72 Asset Management, L.P.COM[CALL]$1.6M<0.1%SH 20,3000000919574-26-005520
Point72 Asset Management, L.P.COM[PUT]$1.1M<0.1%SH 13,9000000919574-26-005520
HORIZON KINETICS ASSET MANAGEMENT LLCCOM$0.9M<0.1%SH 10,9040001398344-26-014047